Tramadol 225mg is a pain reliever which is used for treating moderate and severe pain. In some cases, it is taken continuously to reduce pain and in some cases, it is consumed on demand. It is also used for treating other medical conditions. The maximum dosage is 200mg per day. Tramadol extended-release tablet: If you have severe kidney problems, you should not use these forms of Tramadol. Tramadol 225mg is similar to opioid analgesics. It works in the brain to change how your body feels and responds to pain. Do not increase your dose, take the medication more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed.